The Journal of Dermatology, 2017 · n=609 · rct
Randomized controlled trial (n=609, 12 weeks): Replicates Mills 1986 finding in Asian skin with larger n; 72.7% vs 75.0% vs 41.7% lesion reduction 2.5 vs 5 vs placebo.
Differin
$13.99 · Cleanser
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Ideal for
Caution
May aggravate: Melasma (Benzoyl Peroxide); Atopic Dermatitis / Eczema (Benzoyl Peroxide)
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DIFFERIN Daily Deep Cleanser with 5% BPO was developed by dermatologists and is effective without being abrasive. Get the clearer skin you want, with less redness and irritation.
TARGET ACNE: Penetrates deep into pores with 5% benzoyl peroxide with less irritation & drynessDUAL-ACTION FORMULA: Micronized, dual-action formula absorbs excess oil in the skin, while releasing a gentle moisturizer that won’t clog poresAbsorbs excess oil while releasing a gentle moisturizer that won’t clog pores for face and bodyDERMATOLOGIST-DEVELOPED: Can be used to effectively treat acne or maskne caused by wearing face masks or facial coveringsKey Ingredients5% Benzoyl Peroxide - Acne TreatmentItem 2525874How To UseWet face. Gently massage all over face for about 20-30 seconds, avoiding the eye area. Rinse thoroughly and pat dry. Because excessive drying of the skin may occur, start with one application daily then gradually increase to two or three times daily if needed or as directed by a doctor. If bothersome dryness or peeling occurs, reduce use to once a daily or every other day. If going outside, apply sunscreen after using this product. If irritation or sensitivity develops, stop use of both products and ask a doctor.Precautions: For external use only. When using this product skin irritation and dryness is more likely to occur if you are using another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time. Avoid unnecessary sun exposure and use a sunscreen. Avoid contact with the eyes, lips, and mouth. Avoid co
HSA/FSA eligibleDerm RecommendedSummaryDIFFERIN Daily Deep Cleanser with 5% BPO was developed by dermatologists and is effective without being abrasive. Get the clearer skin you want, with less redness and irritation.DetailsBenefitsTARGET ACNE: Penetrates deep into pores with 5% benzoyl peroxide with less irritation & drynessDUAL-ACTION FORMULA: Micronized, dual-action formula absorbs excess oil in the skin, while releasing a gentle moisturizer that won’t clog poresAbsorbs excess oil while releasing a gentle moisturizer that won’t clog pores for face and bodyDERMATOLOGIST-DEVELOPED: Can be used to effectively treat acne or maskne caused by wearing face masks or facial coveringsKey Ingredients5% Benzoyl Peroxide - Acne TreatmentItem 2525874How To UseWet face. Gently massage all over face for about 20-30 seconds, avoiding the eye area. Rinse thoroughly and pat dry. Because excessive drying of the skin may occur, start with one application daily then gradually increase to two or three times daily if needed or as directed by a doctor. If bothersome dryness or peeling occurs, reduce use to once a daily or every other day. If going outside, apply sunscreen after using this product. If irritation or sensitivity develops, stop use of both products and ask a doctor.Precautions: For external use only. When using this product skin irritation and dryness is more likely to occur if you are
DIFFERIN Daily Deep Cleanser with 5% BPO was developed by dermatologists and is effective without being abrasive. Get the clearer skin you want, with less redness and irritation.DetailsBenefitsTARGET ACNE: Penetrates deep into pores with 5% benzoyl peroxide with less irritation & drynessDUAL-ACTION FORMULA: Micronized, dual-action formula absorbs excess oil in the skin, while releasing a gentle moisturizer that won’t clog poresAbsorbs excess oil while releasing a gentle moisturizer that won’t clog pores for face and bodyDERMATOLOGIST-DEVELOPED: Can be used to effectively treat acne or maskne caused by wearing face masks or facial coveringsKey Ingredients5% Benzoyl Peroxide - Acne TreatmentItem 2525874How To UseWet face. Gently massage all over face for about 20-30 seconds, avoiding the eye area. Rinse thoroughly and pat dry. Because excessive drying of the skin may occur, start with one application daily then gradually increase to two or three times daily if needed or as directed by a doctor. If bothersome dryness or peeling occurs, reduce use to once a daily or every other day. If going outside, apply sunscreen after using this product. If irritation or sensitivity develops, stop use of both products and ask a doctor.Precautions: For external use only. When using this product skin irritation and dryness is more likely to occur if you are using another topical acne medication a
Wet face. Gently massage all over face for about 20-30 seconds, avoiding the eye area. Rinse thoroughly and pat dry. Because excessive drying of the skin may occur, start with one application daily then gradually increase to two or three times daily if needed or as directed by a doctor. If bothersome dryness or peeling occurs, reduce use to once a daily or every other day. If going outside, apply sunscreen after using this product. If irritation or sensitivity develops, stop use of both products and ask a doctor.Precautions: For external use only. When using this product skin irritation and dryness is more likely to occur if you are using another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time. Avoid unnecessary sun exposure and use a sunscreen. Avoid contact with the eyes, lips, and mouth. Avoid contact with hair and dyed fabrics which may be bleached by this product. Skin irritation may occur characterized by redness, burning, itching, peeling, or possibly swelling. Irritation may be reduced by using the product less frequently or in a lower concentration. Do not use if you have very sensitive skin, are sensitive to benzoyl peroxide. Stop use and ask a doctor if: Irritation becomes severe. Keep out of reach of children: If swallowed, get medical help or contact a Poison Control Center right away.IngredientsActive:
BenefitsTARGET ACNE: Penetrates deep into pores with 5% benzoyl peroxide with less irritation & drynessDUAL-ACTION FORMULA: Micronized, dual-action formula absorbs excess oil in the skin, while releasing a gentle moisturizer that won’t clog poresAbsorbs excess oil while releasing a gentle moisturizer that won’t clog pores for face and bodyDERMATOLOGIST-DEVELOPED: Can be used to effectively treat acne or maskne caused by wearing face masks or facial coveringsKey Ingredients5% Benzoyl Peroxide - Acne TreatmentItem 2525874How To UseWet face. Gently massage all over face for about 20-30 seconds, avoiding the eye area. Rinse thoroughly and pat dry. Because excessive drying of the skin may occur, start with one application daily then gradually increase to two or three times daily if needed or as directed by a doctor. If bothersome dryness or peeling occurs, reduce use to once a daily or every other day. If going outside, apply sunscreen after using this product. If irritation or sensitivity develops, stop use of both products and ask a doctor.Precautions: For external use only. When using this product skin irritation and dryness is more likely to occur if you are using another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time. Avoid unnecessary sun exposure and use a sunscreen. Avoid contact with the eyes, lips, and mouth.
Key actives
Active: Benzoyl Peroxide.Inactive: Carbomer, Glycerin, Lauryl Methacrylate/Glycol Dimethacrylate Crosspolymer, Sodium C14-16 Olefin Sulfonate, Sodium Hydroxide, Water.
33 studies on 5of this product’s ingredients. These study the ingredient, not this product.
The Journal of Dermatology, 2017 · n=609 · rct
Randomized controlled trial (n=609, 12 weeks): Replicates Mills 1986 finding in Asian skin with larger n; 72.7% vs 75.0% vs 41.7% lesion reduction 2.5 vs 5 vs placebo.
Cochrane Database of Systematic Reviews, 2020 · systematic-review
Systematic review: Current evidence synthesis confirming BPO efficacy for acne moderate certainty of evidence.
International Journal of Dermatology, 1986 · n=153 · rct
Randomized controlled trial (n=153, 8 weeks): Efficacy equivalence across concentrations with tolerability advantage for 2.5%.
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Community outcomes are self-reported member experiences, shown separately from the evidence score — never blended into it. Educational, not medical advice.