SkinMedica
$64.00 · Serum
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Enhances skin tone and texture Boosts more resilient skin Diminishes appearance of fine lines and coarse wrinkles
Retinol: helps boost collagen production and cell turnover to reduce the appearance of fine lines and deep wrinkles PhytoShield™ Complex: an antioxidant complex, enhancing skin texture and minimizing irritation Key
SkinMedica's Age Defense Retinol Complex .25 is formulated to renew the skin's tone and texture without irritating the skin. Retinol helps combat the signs of premature aging while magnolia bark extract soothes inflammation. Ideal for use twice a week to build tolerance to formula. Key
Apply in the evening after cleansing and toning and before applying your moisturizer. If a retinol product has never been used before, begin twice a week 2-3 days apart, gradually increasing frequency to every other night, and then advancing to each evening or as tolerated. Apply to the entire face. Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with water. Caution: Do not use if you are pregnant, lactating or planning to become pregnant. Mild redness, peeling and irritation are expected when using this product. Use daily sun protection with SPF 30 or higher and limit sun exposure while using this product and for a week following discontinuation.
Key actives
Aqua/Water/Eau, Cetyl Ethylhexanoate, Glycine Soja (Soybean) Oil, Niacinamide, Polyacrylate-13, Squalane, Retinol, Palmitoyl Tripeptide-8, Dunaliella Salina Extract, Magnolia Grandiflora Bark Extract, Tocopherol, Tocotrienols, Ceramide NP, Bisabolol, Tocopheryl Acetate, Oryza Sativa (Rice) Bran Oil, Glycerin, Caprylic/Capric Triglyceride, Polysorbate 20, Butylene Glycol, Cetyl Palmitate, Laureth-23, Trideceth-6 Phosphate, Sodium Hydroxide, Dicaprylyl Ether, Lauryl Alcohol, Polyisobutene, Dextran, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin For the latest information, it is recommended to review the ingredient list printed on the packaging of the product prior to usage or consumption.
72 studies on 14of this product’s ingredients. These study the ingredient, not this product.
Clinics in Dermatology, 2012 · systematic-review
Review of how moisturizers affect the epidermal barrier: humectants such as glycerin increase stratum corneum hydration and can strengthen barrier function and resistance to irritation, although effects depend on formulation and some moisturizers may weaken the barrier; supports well-formulated glycerin-containing emollients for dry, barrier-impaired skin.
British Journal of Dermatology, 2008 · systematic-review
Review establishing glycerin as the gold standard humectant: attracts water to stratum corneum via hydrogen bonding, improves skin mechanical properties (elasticity, pliability), enhances desmosome degradation for smooth desquamation, and modulates aquaporin-3 channels; effective at 2-20% in topical formulations
Dermatologic Therapy, 2004 · systematic-review
Comprehensive review of moisturization mechanisms: glycerin contributes to corneocyte hydration by replacing lost natural moisturizing factor (NMF) components; maintains stratum corneum fluidity at low humidity; superior humectant performance vs propylene glycol, sorbitol, and urea in controlled comparisons
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Community outcomes are self-reported member experiences, shown separately from the evidence score — never blended into it. Educational, not medical advice.