SkinMedica
$96.00 · Serum
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Diminishes appearance of fine lines and coarse wrinkles Enhances skin tone and texture Ideal for all skin types
Retinol: smooths and refines skin's texture and enhances radiance PhytoShield™ Complex: an antioxidant complex, enhances skin texture and minimizes irritation Key
SkinMedica's Age Defense Retinol Complex 1.0 enhances the skin's appearance to promote a smoother, rejuvenated complexion. Formulated for skin types pre-conditioned to retinol treatments, it minimizes the appearance of age spots and wrinkles. It also improves elasticity and works effectively to visibly reduce acne scars. With continued use, faster cell renewal is encouraged. Key
Apply a single pump to face in the evening. If you have never used a retinol product before, begin by limiting use to twice a week, gradually increasing frequency to every other night, and then advancing to each evening or as tolerated. Mild redness, peeling and irritation is expected when using this product. Use daily sun protection with SPF 20 or higher during use of this product. Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with water. CAUTION: Do not use if you are pregnant, lactating or planning to become pregnant.
Key actives
Aqua/Water/Eau, Cetyl Ethylhexanoate, Glycine Soja (Soybean) Oil, Caprylic/Capric Triglyceride, Glycerin, Niacinamide, Polyacrylate-13, Squalane, Polysorbate 20, Retinol, Palmitoyl Tripeptide-8, Dunaliella Salina Extract, Magnolia Grandiflora Bark Extract, Tocopherol, Tocotrienols, Ceramide NP, Bisabolol, Tocopheryl Acetate, Oryza Sativa (Rice) Bran Oil, Butylene Glycol, Cetyl Palmitate, Laureth-23, Trideceth-6 Phosphate, Sodium Hydroxide, Dicaprylyl Ether, Lauryl Alcohol, Polyisobutene, Dextran, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin For the latest information, it is recommended to review the ingredient list printed on the packaging of the product prior to usage or consumption.
72 studies on 14of this product’s ingredients. These study the ingredient, not this product.
Clinics in Dermatology, 2012 · systematic-review
Review of how moisturizers affect the epidermal barrier: humectants such as glycerin increase stratum corneum hydration and can strengthen barrier function and resistance to irritation, although effects depend on formulation and some moisturizers may weaken the barrier; supports well-formulated glycerin-containing emollients for dry, barrier-impaired skin.
British Journal of Dermatology, 2008 · systematic-review
Review establishing glycerin as the gold standard humectant: attracts water to stratum corneum via hydrogen bonding, improves skin mechanical properties (elasticity, pliability), enhances desmosome degradation for smooth desquamation, and modulates aquaporin-3 channels; effective at 2-20% in topical formulations
Dermatologic Therapy, 2004 · systematic-review
Comprehensive review of moisturization mechanisms: glycerin contributes to corneocyte hydration by replacing lost natural moisturizing factor (NMF) components; maintains stratum corneum fluidity at low humidity; superior humectant performance vs propylene glycol, sorbitol, and urea in controlled comparisons
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Community outcomes are self-reported member experiences, shown separately from the evidence score — never blended into it. Educational, not medical advice.