Journal of the American Academy of Dermatology, 2002 · n=24 · rct
RCT in pediatric AD (n=24, ages 2-9): ceramide-dominant barrier repair lipid applied for 12 weeks significantly improved SCORAD scores (p<0.01), reduced TEWL, and normalized stratum corneum lamellar structure on electron microscopy; parents reported reduced pruritus and sleep disturbance