antioxidant
Polyphenol SIRT1 activator and free-radical scavenger; upregulates antioxidant enzymes and inhibits NF-κB inflammatory pathway.
| Concern | Strength | Studies | What the research says |
|---|---|---|---|
| Fine lines & wrinkles | Relevant | 1 | Critical analysis argues the resveratrol-as-SIRT1-activator finding was a methodological artifact of fluorophore-tagged substrates and was not reproduced with native substrates; sirtuins lack the properties of conserved… |
| Dark spots & hyperpigmentation | Relevant | — | Antioxidant + tyrosinase inhibition — real but modest pigment evidence. |
No known conflicts — Resveratrol isn’t flagged against any concern or skin condition.
Strength reflects the ingredient’s effect on each concern; study counts match research whose findings relate to that concern.
Resveratrol is a antioxidant backed by early but promising evidence (evidence tier 3 of 4). We track 3 studies for it. It is typically effective at 0.1–1% in a formulation.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · 2012 · rct · n=900
NIA multi-site replication study: resveratrol (300 and 1200 ppm) failed to extend lifespan in genetically heterogeneous mice at either dose; no significant effect on any measured aging biomarker; directly contradicts earlier claims from industry-adjacent studies in inbred mouse strains
Nature · 2003 · in vitro
Foundational Sinclair lab paper claiming resveratrol activates SIRT1 and extends yeast lifespan by 70%; later shown to be an artifact of the fluorophore-tagged assay substrate (Pacholec et al. 2010); resveratrol does NOT directly activate SIRT1 at physiological concentrations using native substrates
Life Metabolism · 2022 · review
Critical analysis argues the resveratrol-as-SIRT1-activator finding was a methodological artifact of fluorophore-tagged substrates and was not reproduced with native substrates; sirtuins lack the properties of conserved longevity genes, undermining the sirtuin-activation mechanism invoked for resveratrol's purported anti-aging benefits.
In 133 products — most often serums (52), moisturizers (29), eye creams (13), from $4.91 to $814.78. Set up a profile to rank these for your skin. Click any product to learn more.
Dr.Althea
Dr.Althea 345 Relief Cream (Renewal) 50ml
Moisturizer
$27.0050ml · $0.54/ml
Ideal for
Dr.Althea
Dr.Althea 345 Relief Cream (Renewal) 50ml
Moisturizer
$27.0050ml · $0.54/ml
Ideal for
Dr.Althea 345 Relief Cream (Renewal) 50ml is a calming serum by Dr.Althea. Key ingredients include Water, Propanediol, Glycerin.
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Set up your skin profileDIME
TBT Serum with Mandelic Acid + Peptides
Serum
$38.0029.6ml · $1.28/ml
Ideal for
DIME
TBT Serum with Mandelic Acid + Peptides
Serum
$38.0029.6ml · $1.28/ml
Ideal for
TBT Serum with Mandelic Acid + Peptides is a retinoid treatment by DIME. Key ingredients include Water, Mandelic Acid, Propanediol.
Complete your skin profile to see how well this product matches your skin
Set up your skin profileDIME
Serum
$32.0029.6ml · $1.08/ml
Ideal for
DIME
Serum
$32.0029.6ml · $1.08/ml
Ideal for
Hyper Glow Vitamin C Serum is a antioxidant serum by DIME. Key ingredients include Water, L-Ascorbic Acid, Glycerin.
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Set up your skin profileRoC
RoC Derm Correxion® Eye Repair Dark Circle Cream
Moisturizer – for Acne & breakouts, Dryness
$38.99
Ideal for
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Polysorbate 60); Perioral Dermatitis (Fluoride)
RoC
RoC Derm Correxion® Eye Repair Dark Circle Cream
Moisturizer – for Acne & breakouts, Dryness
$38.99
Ideal for
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Polysorbate 60); Perioral Dermatitis (Fluoride)
RoC Derm Correxion® Eye Repair Dark Circle Cream is a retinoid treatment by RoC. Key ingredients include Water, Caprylic/Capric Triglyceride, Squalane.
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Set up your skin profile
L'Oréal Professionnel
L'Oréal Professionnel Serie Expert Vitamino Color Mask 250ml
Serum
$36.20250ml · $0.14/ml
Ideal for
Caution
May aggravate: Seborrheic Dermatitis (Stearyl Alcohol); Atopic Dermatitis / Eczema (Propylene Glycol); Rosacea (Propylene Glycol and Linalool)
L'Oréal Professionnel
L'Oréal Professionnel Serie Expert Vitamino Color Mask 250ml
Serum
$36.20250ml · $0.14/ml
Ideal for
Caution
May aggravate: Seborrheic Dermatitis (Stearyl Alcohol); Atopic Dermatitis / Eczema (Propylene Glycol); Rosacea (Propylene Glycol and Linalool)
L'Oréal Professionnel Serie Expert Vitamino Color Mask 250ml is a brightening serum by L'Oréal Professionnel. Key ingredients include Stearyl Alcohol, Propylene Glycol, Phenoxyethanol.
Complete your skin profile to see how well this product matches your skin
Set up your skin profileBubble
Morning Rays Brightening Eye Cream
Eye Cream
$14.9914.8ml · $1.01/ml
Ideal for
Caution
May aggravate: Seborrheic Dermatitis (Ethylhexyl Palmitate, Cetearyl Alcohol and Jojoba Oil)
Bubble
Morning Rays Brightening Eye Cream
Eye Cream
$14.9914.8ml · $1.01/ml
Ideal for
Caution
May aggravate: Seborrheic Dermatitis (Ethylhexyl Palmitate, Cetearyl Alcohol and Jojoba Oil)
Morning Rays Brightening Eye Cream is a eye cream by Bubble. Key ingredients include Water, Glycerin, Ethylhexyl Palmitate.
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Set up your skin profileEstée Lauder
Perfectionist Pro Rapid Brightening Serum with Ferment3 + Vitamin C - 1.0 oz
Serum
$100.0029.6ml · $3.38/ml
Ideal for
Not recommended for
Caution
May aggravate: Psoriasis (Fragrance); Perioral Dermatitis (Fragrance); Melasma (Fragrance)
Estée Lauder
Perfectionist Pro Rapid Brightening Serum with Ferment3 + Vitamin C - 1.0 oz
Serum
$100.0029.6ml · $3.38/ml
Ideal for
Not recommended for
Caution
May aggravate: Psoriasis (Fragrance); Perioral Dermatitis (Fragrance); Melasma (Fragrance)
Perfectionist Pro Rapid Brightening Serum with Ferment3 + Vitamin C - 1.0 oz is a exfoliant by Estée Lauder. Key ingredients include Butylene Glycol, Glycerin, Dimethicone.
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Set up your skin profileStriVectin
SD Advanced PLUS Intensive Moisturizer - 2.0 oz
Moisturizer
$85.0059.1ml · $1.44/ml
Ideal for
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Cetearyl Alcohol, Glyceryl Stearate, Shea Butter and Polysorbate 60); Perioral Dermatitis (Fragrance)
StriVectin
SD Advanced PLUS Intensive Moisturizer - 2.0 oz
Moisturizer
$85.0059.1ml · $1.44/ml
Ideal for
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Cetearyl Alcohol, Glyceryl Stearate, Shea Butter and Polysorbate 60); Perioral Dermatitis (Fragrance)
SD Advanced PLUS Intensive Moisturizer - 2.0 oz is a exfoliant by StriVectin. Key ingredients include Glycerin, Propanediol, Cetearyl Alcohol.
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Set up your skin profile
Dr. Dennis Gross
Alpha Beta Universal Daily Peel
Exfoliant – for Uneven texture, Fine lines & wrinkles
$26.32
Ideal for
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Polysorbate 80); Perioral Dermatitis (Fragrance)
Dr. Dennis Gross
Alpha Beta Universal Daily Peel
Exfoliant – for Uneven texture, Fine lines & wrinkles
$26.32
Ideal for
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Polysorbate 80); Perioral Dermatitis (Fragrance)
Alpha Beta Universal Daily Peel is a exfoliant by Dr. Dennis Gross. Key ingredients include Alcohol Denat, Glycolic Acid, Polysorbate 20.
Complete your skin profile to see how well this product matches your skin
Set up your skin profileMad Hippie
Moisturizer
$27.9929.6ml · $0.95/ml
Ideal for
Not recommended for
Mad Hippie
Moisturizer
$27.9929.6ml · $0.95/ml
Ideal for
Not recommended for
Face Cream is a basic moisturiser by Mad Hippie. Key ingredients include Water, Cetearyl Alcohol, Glycerin.
Complete your skin profile to see how well this product matches your skin
Set up your skin profileEducational information, not medical advice. Study findings summarise the cited research and may not reflect every formulation.