humectant
| Concern | Strength | Studies | What the research says |
|---|---|---|---|
| Dryness | Relevant | 2 | Combining Aloe vera extract with trimethylglycine (betaine), an osmolyte humectant, synergistically upregulated aquaporin-3 by up to 380% in vitro. In a 60-subject 28-day study, epidermal hydration rose 236% five… |
No known conflicts — Betaine isn’t flagged against any concern or skin condition.
Strength reflects the ingredient’s effect on each concern; study counts match research whose findings relate to that concern.
Betaine is a humectant backed by early but promising evidence (evidence tier 3 of 4). We track 2 studies for it, 2 reporting a positive effect.
Molecules · 2024 · observational · n=60
Combining Aloe vera extract with trimethylglycine (betaine), an osmolyte humectant, synergistically upregulated aquaporin-3 by up to 380% in vitro. In a 60-subject 28-day study, epidermal hydration rose 236% five minutes after a single application and 25.4% after 28 days with the optimized trimethylglycine/aloe formulation.
Skin Research and Technology · 2003 · observational · n=28
In 28 healthy subjects, commercial soaps with and without betaine were patch-tested for 24 h and assessed by visual inspection, transepidermal water loss and electrical impedance. Soaps containing betaine were the least irritating, though irritation did not decrease further at higher betaine concentrations; non-invasive methods detected subtle reactions better than visual scoring.
In 1,302 products — most often serums (490), moisturizers (365), masks (123), from $3.00 to $720.49. Set up a profile to rank these for your skin. Click any product to learn more.
Klairs
Supple Preparation Unscented Toner
Toner
$22.00179.8ml · $0.12/ml
Ideal for
Klairs
Supple Preparation Unscented Toner
Toner
$22.00179.8ml · $0.12/ml
Ideal for
Supple Preparation Unscented Toner is a calming serum by Klairs. Key ingredients include Water, Butylene Glycol, Betaine.
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ELEMIS
Elemis Dynamic Resurfacing Facial Pads (14 Pads)
Serum – for Dryness, Dark spots & hyperpigmentation
$25.00
Ideal for
Not recommended for
Caution
May aggravate: Psoriasis (Lactic Acid and Fragrance); Melasma (Fragrance); Perioral Dermatitis (Fragrance); Seborrheic Dermatitis (Shea Butter and Stearyl Alcohol)
ELEMIS
Elemis Dynamic Resurfacing Facial Pads (14 Pads)
Serum – for Dryness, Dark spots & hyperpigmentation
$25.00
Ideal for
Not recommended for
Caution
May aggravate: Psoriasis (Lactic Acid and Fragrance); Melasma (Fragrance); Perioral Dermatitis (Fragrance); Seborrheic Dermatitis (Shea Butter and Stearyl Alcohol)
Elemis Dynamic Resurfacing Facial Pads (14 Pads) is a exfoliant by ELEMIS. Key ingredients include Butylene Glycol, Polysorbate 20, Lactic Acid.
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ESPA
ESPA Tri-Active Lift and Firm Eye Serum 15ml
Eye Cream
$64.7715ml · $4.32/ml
Ideal for
Caution
May aggravate: Atopic Dermatitis / Eczema (Salicylic Acid)
ESPA
ESPA Tri-Active Lift and Firm Eye Serum 15ml
Eye Cream
$64.7715ml · $4.32/ml
Ideal for
Caution
May aggravate: Atopic Dermatitis / Eczema (Salicylic Acid)
ESPA Tri-Active Lift and Firm Eye Serum 15ml is a eye cream by ESPA. Key ingredients include Water, Glycerin, Betaine.
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Nip + Fab
NIP+FAB Ceramide Fix Serum 12% 50ml
Serum
$37.0850ml · $0.74/ml
Ideal for
Caution
May aggravate: Atopic Dermatitis / Eczema (Azelaic Acid)
Nip + Fab
NIP+FAB Ceramide Fix Serum 12% 50ml
Serum
$37.0850ml · $0.74/ml
Ideal for
Caution
May aggravate: Atopic Dermatitis / Eczema (Azelaic Acid)
NIP+FAB Ceramide Fix Serum 12% 50ml is a brightening serum by Nip + Fab. Key ingredients include Butylene Glycol, Niacinamide, Glycerin.
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Angela Caglia Skincare
Angela Caglia Cell Forté Serum 30ml
Serum
$325.0030ml · $10.83/ml
Ideal for
Angela Caglia Skincare
Angela Caglia Cell Forté Serum 30ml
Serum
$325.0030ml · $10.83/ml
Ideal for
Angela Caglia Cell Forté Serum 30ml is a brightening serum by Angela Caglia Skincare. Key ingredients include Water, Propanediol, Alanine.
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Set up your skin profilePEACH & LILY
Lazy Day All-In-One Moisture Pads
Toner
$43.00
Ideal for
PEACH & LILY
Lazy Day All-In-One Moisture Pads
Toner
$43.00
Ideal for
Lazy Day All-In-One Moisture Pads is a hydrating serum by PEACH & LILY. Key ingredients include Water, Butylene Glycol, Glycerin.
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Set up your skin profileflorence by mills
Plump To It! Hydrating Facial Moisturizer
Moisturizer
$24.0050.3ml · $0.48/ml
Ideal for
Not recommended for
florence by mills
Plump To It! Hydrating Facial Moisturizer
Moisturizer
$24.0050.3ml · $0.48/ml
Ideal for
Not recommended for
Plump To It! Hydrating Facial Moisturizer is a basic moisturiser by florence by mills. Key ingredients include Glycerin, 1,2-Hexanediol, Cetyl Ethylhexanoate.
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Set up your skin profileDIME
Dewy Day Cream with Rosehip + Tremella
Moisturizer
$38.0050.3ml · $0.76/ml
Ideal for
Caution
May aggravate: Seborrheic Dermatitis (Cetearyl Alcohol, Glyceryl Stearate and Linoleic Acid)
DIME
Dewy Day Cream with Rosehip + Tremella
Moisturizer
$38.0050.3ml · $0.76/ml
Ideal for
Caution
May aggravate: Seborrheic Dermatitis (Cetearyl Alcohol, Glyceryl Stearate and Linoleic Acid)
Dewy Day Cream with Rosehip + Tremella is a barrier moisturiser by DIME. Key ingredients include Water, Cetearyl Alcohol, Glycerin.
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Lotus Youth Preserve Line & Texture Smoothing Moisturizer - 1.6 oz
Moisturizer
$59.0047.3ml · $1.25/ml
Ideal for
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Cetearyl Alcohol, Ethylhexyl Palmitate, Cetyl Alcohol and Stearyl Alcohol); Rosacea (Citrus Oils and Limonene)
Fresh
Lotus Youth Preserve Line & Texture Smoothing Moisturizer - 1.6 oz
Moisturizer
$59.0047.3ml · $1.25/ml
Ideal for
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Cetearyl Alcohol, Ethylhexyl Palmitate, Cetyl Alcohol and Stearyl Alcohol); Rosacea (Citrus Oils and Limonene)
Lotus Youth Preserve Line & Texture Smoothing Moisturizer - 1.6 oz is a antioxidant serum by Fresh. Key ingredients include Water, Glycerin, Cetearyl Alcohol.
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Perricone MD
Perricone MD Hypoallergenic Clean Correction Nourishing Moisturiser 59ml
Moisturizer
$81.2859ml · $1.38/ml
Ideal for
Caution
May aggravate: Seborrheic Dermatitis (Glyceryl Stearate)
Perricone MD
Perricone MD Hypoallergenic Clean Correction Nourishing Moisturiser 59ml
Moisturizer
$81.2859ml · $1.38/ml
Ideal for
Caution
May aggravate: Seborrheic Dermatitis (Glyceryl Stearate)
Perricone MD Hypoallergenic Clean Correction Nourishing Moisturiser 59ml is a antioxidant serum by Perricone MD. Key ingredients include Betaine, Coco-Caprylate, Glycerin.
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Set up your skin profileEducational information, not medical advice. Study findings summarise the cited research and may not reflect every formulation.