surfactant irritant
Model irritant in dermatology research. Denatures stratum corneum proteins, solubilizes intercellular lipids, causes keratinocyte cytotoxicity, and triggers IL-1α release. Dose-dependent barrier disruption.
Sodium Lauryl Sulfate is a surfactant irritant backed by a large, consistent body of clinical evidence (evidence tier 1 of 4). We track 3 studies for it, 3 reporting a positive effect.
Contact Dermatitis · 1995 · systematic review
Comprehensive review establishing SLS as the model irritant: mechanisms include protein denaturation of stratum corneum keratins, solubilization of intercellular lipid lamellae, direct keratinocyte cytotoxicity, and IL-1α release triggering inflammatory cascade; barrier recovery takes 5-7 days after single 24-hour SLS exposure
Contact Dermatitis · 2003 · rct · n=50
Irritant patch-test profile of detergents found sodium lauryl sulfate (SLS) produced the strongest irritant reactions versus sodium laureth sulfate and alkyl polyglucoside, supporting SLS as the most irritant of these common detergents and its use as the reference irritant.
Journal of Investigative Dermatology · 1990 · rct · n=20
Classic dose-response study (n=20): SLS produced concentration-dependent irritant contact dermatitis; TEWL increased linearly with SLS concentration (0.25-2%); barrier disruption was detectable at concentrations as low as 0.5% with 24-hour occlusion; established the gold standard SLS patch test methodology
In 110 products — most often cleansers (42), moisturizers (30), serums (24), from $12.05 to $357.25. Set up a profile to rank these for your skin. Click any product to learn more.
Shiseido
Cleanser
$39.00136ml · $0.29/ml
Ideal for
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Myristic Acid and Lauric Acid); Melasma (Fragrance)
Shiseido
Cleanser
$39.00136ml · $0.29/ml
Ideal for
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Myristic Acid and Lauric Acid); Melasma (Fragrance)
Clarifying Cleansing Foam is a water cleanser by Shiseido. Key ingredients include Water, Stearic Acid, Myristic Acid.
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Natura
Natura Bissé Stabilizing Facial Cleansing Gel with AHA and PHA 200ml
Exfoliant
$67.31200ml · $0.34/ml
Ideal for
Not recommended for
Caution
May aggravate: Melasma (Fragrance)
Natura
Natura Bissé Stabilizing Facial Cleansing Gel with AHA and PHA 200ml
Exfoliant
$67.31200ml · $0.34/ml
Ideal for
Not recommended for
Caution
May aggravate: Melasma (Fragrance)
Natura Bissé Stabilizing Facial Cleansing Gel with AHA and PHA 200ml is a exfoliant by Natura. Key ingredients include Sodium Laureth Sulfate, Cocamidopropyl Betaine, Glycolic Acid.
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Cetaphil
Cleanser – for Dryness, Redness & sensitivity
$34.921.0L · $0.04/ml
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Cetyl Alcohol and Stearyl Alcohol)
Cetaphil
Cleanser – for Dryness, Redness & sensitivity
$34.921.0L · $0.04/ml
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Cetyl Alcohol and Stearyl Alcohol)
Cetaphil Gentle Skin Cleanser is a water cleanser by Cetaphil. Key ingredients include Water, Cetyl Alcohol, Propylene Glycol.
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Neutrogena
Neutrogena Hydro Boost Water Gel Facial Cleanser for Dry or Dehydrated Skin 200ml
Cleanser
$12.05200ml · $0.06/ml
Ideal for
Not recommended for
Caution
May aggravate: Melasma (Fragrance)
Neutrogena
Neutrogena Hydro Boost Water Gel Facial Cleanser for Dry or Dehydrated Skin 200ml
Cleanser
$12.05200ml · $0.06/ml
Ideal for
Not recommended for
Caution
May aggravate: Melasma (Fragrance)
Neutrogena Hydro Boost Water Gel Facial Cleanser for Dry or Dehydrated Skin 200ml is a water cleanser by Neutrogena. Key ingredients include Water, Glycerin, Hyaluronic Acid.
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Set up your skin profileNeutrogena
Neutrogena Hydro Boost Hydrating Cleansing Gel
Cleanser – for Dryness, Dark spots & hyperpigmentation
$16.49
Ideal for
Not recommended for
Caution
May aggravate: Melasma (Fragrance)
Neutrogena
Neutrogena Hydro Boost Hydrating Cleansing Gel
Cleanser – for Dryness, Dark spots & hyperpigmentation
$16.49
Ideal for
Not recommended for
Caution
May aggravate: Melasma (Fragrance)
Neutrogena Hydro Boost Hydrating Cleansing Gel is a water cleanser by Neutrogena. Key ingredients include Water, Glycerin, Hyaluronic Acid.
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Natura
Natura Bissé Stabilizing Cleansing Mask 75ml
Cleanser
$59.6975ml · $0.80/ml
Ideal for
Not recommended for
Natura
Natura Bissé Stabilizing Cleansing Mask 75ml
Cleanser
$59.6975ml · $0.80/ml
Ideal for
Not recommended for
Natura Bissé Stabilizing Cleansing Mask 75ml is a water cleanser by Natura. Key ingredients include Water, Propylene Glycol, Alcohol Denat.
Complete your skin profile to see how well this product matches your skin
Set up your skin profileClarins
V-Facial Instant Depuffing Face Mask
Mask
$75.0073.9ml · $1.01/ml
Ideal for
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Cetearyl Alcohol, Cetyl Alcohol and Glyceryl Stearate)
Clarins
V-Facial Instant Depuffing Face Mask
Mask
$75.0073.9ml · $1.01/ml
Ideal for
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Cetearyl Alcohol, Cetyl Alcohol and Glyceryl Stearate)
V-Facial Instant Depuffing Face Mask is a mask by Clarins. Key ingredients include Water, Glycerin, Alcohol Denat.
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Set up your skin profileClarins
Super Restorative Neck and Décolleté Cream
Moisturizer
$120.0071ml · $1.69/ml
Ideal for
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Shea Butter and Cetearyl Alcohol)
Clarins
Super Restorative Neck and Décolleté Cream
Moisturizer
$120.0071ml · $1.69/ml
Ideal for
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Shea Butter and Cetearyl Alcohol)
Super Restorative Neck and Décolleté Cream is a antioxidant serum by Clarins. Key ingredients include Coco-Caprylate/Caprate, Glycerin, Shea Butter.
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Piz Buin
Piz Buin Tan & Protect Tan Intensifying Sun Oil Spray - Medium SPF15 150ml
Serum
$12.69150ml · $0.09/ml
Ideal for
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Cetearyl Alcohol); Melasma (Fragrance)
Piz Buin
Piz Buin Tan & Protect Tan Intensifying Sun Oil Spray - Medium SPF15 150ml
Serum
$12.69150ml · $0.09/ml
Ideal for
Not recommended for
Caution
May aggravate: Seborrheic Dermatitis (Cetearyl Alcohol); Melasma (Fragrance)
Piz Buin Tan & Protect Tan Intensifying Sun Oil Spray - Medium SPF15 150ml is a antioxidant serum by Piz Buin. Key ingredients include Water, C12-15 Alkyl Benzoate, Octocrylene.
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Dermalogica
Dermalogica Clear Start Breakout Clearing Foaming Wash
Serum – for Dryness, sensitivity
$24.13177ml · $0.14/ml
Ideal for
Not recommended for
Caution
May aggravate: Melasma (Bergamot Oil)
Dermalogica
Dermalogica Clear Start Breakout Clearing Foaming Wash
Serum – for Dryness, sensitivity
$24.13177ml · $0.14/ml
Ideal for
Not recommended for
Caution
May aggravate: Melasma (Bergamot Oil)
Dermalogica Clear Start Breakout Clearing Foaming Wash is a hydrating serum by Dermalogica. Key ingredients include Water, Sodium Lauroyl Sarcosinate, Lavender Oil.
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Set up your skin profileEducational information, not medical advice. Study findings summarise the cited research and may not reflect every formulation.