retinoid

Hydroxypinacolone Retinoate

Evidenceemerging · Tier 3Irritation riskLowEffective range0.1–1%In products67

Retinoic acid ester that binds retinoid receptors directly without enzymatic conversion. Claimed to deliver retinoid benefits with minimal irritation, though independent evidence is limited.

The research

Hydroxypinacolone Retinoate is a retinoid backed by early but promising evidence (evidence tier 3 of 4). We track 2 studies for it, 2 reporting a positive effect. It is typically effective at 0.1–1% in a formulation.

Read the research — 2 studies

Pharmaceutics · 2023 · in vitro

Encapsulating retinol propionate and hydroxypinacolone retinoate in supramolecular nanoparticles gave high stability, low irritation and sustained release; the formulation significantly increased type I collagen synthesis in human dermal fibroblasts (p<0.01), and facial imaging showed visibly reduced wrinkles over 56 days of use.

Products with Hydroxypinacolone Retinoate

In 67 products — most often serums (48), moisturizers (11), eye creams (6), from $4.75 to $250.70. Set up a profile to rank these for your skin. Click any product to learn more.

10 of 24
Elizabeth Arden

Elizabeth Arden

Elizabeth Arden Retinol + HPR Ceramide Capsules Rapid Skin Renewing Serum 90 Capsules

Serum

$125.73

★★★★★4.8(978)

Ideal for

  • StrongLoss of firmness
  • GoodFine lines & wrinkles
  • GoodDryness
  • GoodDark circles

Not recommended for

Atopic Dermatitis / EczemaPsoriasis

Caution

May aggravate: Seborrheic Dermatitis (Shea Butter)

Elizabeth Arden Retinol + HPR Ceramide Capsules Rapid Skin Renewing Serum 90 Capsules is a retinoid treatment by Elizabeth Arden. Key ingredients include Cyclopentasiloxane, Dimethicone, C12-15 Alkyl Benzoate.

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Elizabeth Arden

Elizabeth Arden

Elizabeth Arden Retinol + HPR Ceramide Capsules Rapid Skin Renewing Serum 60 Capsules

Serum

$107.95

★★★★★4.8(977)

Ideal for

  • StrongLoss of firmness
  • GoodFine lines & wrinkles
  • GoodDryness
  • GoodDark circles

Not recommended for

Atopic Dermatitis / EczemaPsoriasis

Caution

May aggravate: Seborrheic Dermatitis (Shea Butter)

Elizabeth Arden Retinol + HPR Ceramide Capsules Rapid Skin Renewing Serum 60 Capsules is a retinoid treatment by Elizabeth Arden. Key ingredients include Cyclopentasiloxane, Dimethicone, C12-15 Alkyl Benzoate.

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Elizabeth Arden

Elizabeth Arden

Ceramide Retinol + HPR Rapid Skin Renewing Water Cream

Moisturizer

$103.0050.3ml · $2.05/ml

★★★★★4.7(1,320)

Ideal for

  • GoodFine lines & wrinkles
  • GoodDryness
  • GoodLoss of firmness
  • GoodDark circles

Not recommended for

Atopic Dermatitis / EczemaPsoriasisRosacea

Caution

May aggravate: Seborrheic Dermatitis (Shea Butter and Glyceryl Stearate); Melasma (Fragrance); Perioral Dermatitis (Fragrance)

Ceramide Retinol + HPR Rapid Skin Renewing Water Cream is a retinoid treatment by Elizabeth Arden. Key ingredients include Caprylic/Capric Triglyceride, Glycerin, Pentylene Glycol.

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Sunday Riley

Sunday Riley

Luna Retinol Sleeping Night Oil - 0.5 oz

Serum

$55.0014.8ml · $3.72/ml

★★★★★4.6(1,346)

Caution

May aggravate: Rosacea (Linalool and Limonene)

Luna Retinol Sleeping Night Oil - 0.5 oz is a retinoid treatment by Sunday Riley. Key ingredients include Hydroxypinacolone Retinoate, Rosmarinus Officinalis Leaf Extract, Linalool.

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Pacifica

Pacifica

Wake Up Beautiful Overnight Retinoid Cream

Moisturizer

$24.0050.3ml · $0.48/ml

★★★★★4.6(889)

Ideal for

  • RelevantDryness
  • LowUneven texture

Wake Up Beautiful Overnight Retinoid Cream is a retinoid treatment by Pacifica. Key ingredients include Water, Glyceryl Stearate SE, Glycerin.

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Elizabeth Arden

Elizabeth Arden

Retinol + HPR Ceramide Capsules Rapid Skin Renewing Serum - 30 ct

Serum

$56.00

★★★★★4.6(11,776)

Ideal for

  • StrongLoss of firmness
  • GoodFine lines & wrinkles
  • GoodDryness
  • RelevantDark circles

Not recommended for

Atopic Dermatitis / EczemaPsoriasis

Caution

May aggravate: Seborrheic Dermatitis (Shea Butter)

Retinol + HPR Ceramide Capsules Rapid Skin Renewing Serum - 30 ct is a retinoid treatment by Elizabeth Arden. Key ingredients include Cyclopentasiloxane, Dimethicone, C12-15 Alkyl Benzoate.

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Clinique

Clinique

Clinique Smart Clinical Repair Am/pm Retinoid Balm

Serum – for Dryness, Dark spots & hyperpigmentation

$37.003ml · $12.28/ml

★★★★★4.5(560)

Ideal for

  • RelevantFine lines & wrinkles
  • RelevantDryness
  • LowRedness & sensitivity

Caution

May aggravate: Seborrheic Dermatitis (Shea Butter and Glyceryl Stearate)

Clinique Smart Clinical Repair Am/pm Retinoid Balm is a retinoid treatment by Clinique. Key ingredients include Squalane, Shea Butter, Silica.

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The Ordinary

The Ordinary

Granactive Retinoid 2% Emulsion for Wrinkles and Uneven Texture

Moisturizer

$12.1029.6ml · $0.41/ml

★★★★★4.5(1,066)

Ideal for

  • GoodLoss of firmness
  • RelevantFine lines & wrinkles
  • RelevantDark circles
  • RelevantDryness

Not recommended for

Atopic Dermatitis / EczemaPsoriasis

Caution

May aggravate: Seborrheic Dermatitis (Glyceryl Stearate and Cetearyl Alcohol)

Granactive Retinoid 2% Emulsion for Wrinkles and Uneven Texture is a retinoid treatment by The Ordinary. Key ingredients include Water, Glycerin, Propanediol.

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Murad

Murad

Murad Retinol Youth Renewal Serum

Serum – for Acne & breakouts, Dryness

$92.0029.6ml · $3.11/ml

★★★★★4.4(6,910)

Ideal for

  • GoodFine lines & wrinkles
  • GoodDryness
  • GoodLoss of firmness
  • RelevantDark circles

Not recommended for

Atopic Dermatitis / EczemaPsoriasisRosacea

Caution

May aggravate: Seborrheic Dermatitis (Isopropyl Palmitate, Glyceryl Stearate and Ethylhexyl Palmitate); Melasma (Fragrance); Perioral Dermatitis (Fragrance)

Clinique

Clinique

Clinique Smart Clinical Repair™ Wrinkle Correcting Serum

Serum – for barrier_repair, Dryness

$80.0029.6ml · $2.71/ml

★★★★★4.4(9,324)

Ideal for

  • GoodFine lines & wrinkles
  • GoodDryness
  • GoodLoss of firmness
  • LowUneven texture

Not recommended for

Acne & breakouts

Caution

May aggravate: Seborrheic Dermatitis (Polysorbate 80)

Clinique Smart Clinical Repair™ Wrinkle Correcting Serum is a retinoid treatment by Clinique. Key ingredients include Dimethicone, Butylene Glycol, Glycerin.

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Educational information, not medical advice. Study findings summarise the cited research and may not reflect every formulation.