Disrupts stratum corneum lipid bilayer, increases TEWL, causes vasodilation, and enhances penetration of other irritants. Dissolves protective ceramides and fatty acids from the skin barrier.
The research
Alcohol Denat is a irritant backed by a large, consistent body of clinical evidence (evidence tier 1 of 4). We track 3 studies for it, 1 reporting a positive effect.
Journal of Occupational Medicine and Toxicology · 2008 · systematic review
Review of ethanol effects on skin: ethanol disrupts the stratum corneum lipid bilayer in a dose-dependent manner, increases TEWL, and extracts intercellular ceramides; at concentrations >30% (common in toners and astringents), causes measurable barrier dysfunction within 30 minutes of application
British Journal of Dermatology · 2007 · rct · n=30
Controlled human irritation study: alcohols (notably ethanol) showed low irritation potential, producing no significant barrier disruption or erythema even when applied to skin pre-irritated with the detergent SLS; indicates alcohol is a comparatively weak skin irritant rather than a major barrier-damaging agent.
International Journal of Cosmetic Science · 2016 · observational · n=24
Comparison of ethanol, isopropanol and n-propanol: isopropanol and n-propanol caused significant stratum corneum and keratinocyte perturbation in vitro plus impaired skin condition in vivo, whereas ethanol did not; ethanol was the best-tolerated alcohol for skin contact.
Products with Alcohol Denat
In 1,758 products — most often serums (624), moisturizers (453), sunscreens (345), from $4.37 to $1115.62. Set up a profile to rank these for your skin. Click any product to learn more.
La Roche-Posay Anthelios UVMune 400 Dermo-Pediatrics Kids Ultra Light Invinsible Fluid SPF 50+ 50ml is a sunscreen by La Roche-Posay. Key ingredients include Bemotrizinol, Alcohol Denat, Ethylhexyl Triazone.
Eucerin Sun Face Hydro Protect Ultra Light Fluid SPF50 50ml is a hydrating serum by Eucerin. Key ingredients include Water, Alcohol Denat, C12-15 Alkyl Benzoate.
VICHY Capital Soleil UV Age Daily SPF 50+ Invisible Sun Cream with Niacinamide 40ml is a sunscreen by Vichy. Key ingredients include Alcohol Denat, Silica, Isopropyl Myristate.
Lancôme Rénergie Multi-Lift Night Cream 50ml is a peptide serum by Lancôme. Key ingredients include Glycerin, Caprylic/Capric Triglyceride, Cetyl Alcohol.
Wella Professionals Care Oil Reflections Luminous Smoothing Oil 100ml is a antioxidant serum by Wella Professionals. Key ingredients include Cyclopentasiloxane, Dimethiconol, Alcohol Denat.