humectant preservative

1,2-Hexanediol

Evidenceformulation · Tier 4Irritation riskLowIn products4,191

The research

1,2-Hexanediol is a humectant preservative backed by documented evidence (evidence tier 4 of 4). We track 2 studies for it, 2 reporting a positive effect.

Read the research — 2 studies

Cutaneous and Ocular Toxicology · 2009 · observational · n=200

In a 200-subject repeat-insult patch test, a 15% blend of 1,2-hexanediol and caprylyl glycol in carbomer gel and in a use-level cosmetic formulation produced no delayed Type IV hypersensitivity (sensitization) reactions, supporting the dermal safety of the preservative system.

Letters in Applied Microbiology · 2015 · in vitro

1,2-Hexanediol showed broad-spectrum antibacterial activity (MIC 0.5-2% v/v) against Gram-positive and Gram-negative bacteria by depolarizing the cytoplasmic membrane; combining it with food-grade antimicrobials (macelignan, octyl gallate) lowered its effective concentration to 0.25-0.5x MIC against Gram-positive bacteria.

Products with 1,2-Hexanediol

In 4,191 products — most often serums (1360), moisturizers (1168), cleansers (365), from $2.51 to $1786.24. Set up a profile to rank these for your skin. Click any product to learn more.

10 of 24
Caudalie

Caudalie

Caudalie Pore Minimizing Instant Detox Mask 75ml

Serum

$33.0275ml · $0.44/ml

★★★★★4.8(2,048)

Ideal for

  • ExcellentDryness
  • RelevantUneven texture
  • RelevantFine lines & wrinkles
  • RelevantDark spots & hyperpigmentation

Not recommended for

Atopic Dermatitis / EczemaRosaceaPsoriasisMelasma

Caudalie Pore Minimizing Instant Detox Mask 75ml is a exfoliant by Caudalie. Key ingredients include Glycerin, Xanthan Gum, Benzyl Alcohol.

Complete your skin profile to see how well this product matches your skin

Set up your skin profile
Erborian

Erborian

Erborian Ginseng Super Serum - 30ml

Serum

$50.8030ml · $1.69/ml

★★★★★4.8(858)

Ideal for

  • StrongDryness
  • StrongFine lines & wrinkles
  • RelevantDark spots & hyperpigmentation
  • RelevantRedness & sensitivity

Not recommended for

Rosacea

Erborian Ginseng Super Serum - 30ml is a peptide serum by Erborian. Key ingredients include Propanediol, 1,2-Hexanediol, Butylene Glycol.

Complete your skin profile to see how well this product matches your skin

Set up your skin profile
BYOMA

BYOMA

BYOMA Hydrating Milky Toner 150ml

Toner – for Dryness, Redness & sensitivity

$15.03150ml · $0.10/ml

★★★★★4.8(1,357)

Ideal for

  • ExcellentDryness
  • StrongRedness & sensitivity
  • StrongFine lines & wrinkles

BYOMA Hydrating Milky Toner 150ml is a calming serum by BYOMA. Key ingredients include Water, Butylene Glycol, Glycerin.

Complete your skin profile to see how well this product matches your skin

Set up your skin profile
Caudalie

Caudalie

Caudalie Vinoperfect Brightening Glycolic Peel Mask 75ml

Exfoliant

$36.8375ml · $0.49/ml

★★★★★4.8(3,016)

Ideal for

  • ExcellentDryness
  • RelevantRedness & sensitivity
  • RelevantBlackheads
  • RelevantDark spots & hyperpigmentation

Not recommended for

MelasmaAtopic Dermatitis / EczemaRosaceaPsoriasisPerioral Dermatitis

Caudalie Vinoperfect Brightening Glycolic Peel Mask 75ml is a exfoliant by Caudalie. Key ingredients include Glycolic Acid, Panthenol, Dimethicone.

Complete your skin profile to see how well this product matches your skin

Set up your skin profile
Caudalie

Caudalie

Caudalie Vinoperfect Brightening Daily AHA Micropeel 100ml

Exfoliant – for Dryness

$24.13100ml · $0.24/ml

★★★★★4.7(1,449)

Ideal for

  • StrongDryness
  • RelevantAcne & breakouts
  • RelevantBlackheads
  • RelevantDark spots & hyperpigmentation

Not recommended for

MelasmaAtopic Dermatitis / EczemaRosaceaPerioral DermatitisPsoriasis

Caudalie Vinoperfect Brightening Daily AHA Micropeel 100ml is a exfoliant by Caudalie. Key ingredients include Glycerin, Coco-Glucoside, Mandelic Acid.

Complete your skin profile to see how well this product matches your skin

Set up your skin profile
Nip + Fab

Nip + Fab

NIP+FAB Hyaluronic Fix Extreme4 Hydration Jelly Eye Patches (20 Pairs)

Serum

$25.34

★★★★★4.7(1,641)

Ideal for

  • StrongDryness
  • RelevantRedness & sensitivity
  • RelevantFine lines & wrinkles

NIP+FAB Hyaluronic Fix Extreme4 Hydration Jelly Eye Patches (20 Pairs) is a hydrating serum by Nip + Fab. Key ingredients include Glycerin, Hyaluronic Acid, Xanthan Gum.

Product Ingredients (7)

Irritation risk: unlikely possible likely

Complete your skin profile to see how well this product matches your skin

Set up your skin profile
Perricone MD

Perricone MD

Perricone MD Essential Fx Acyl-Glutathione Chia Cleansing Balm 96g

Cleanser

$29.7296ml · $0.31/ml

★★★★★4.7(900)

Not recommended for

Seborrheic DermatitisAtopic Dermatitis / EczemaRosaceaPerioral DermatitisPsoriasisMelasma

Perricone MD Essential Fx Acyl-Glutathione Chia Cleansing Balm 96g is a oil cleanser by Perricone MD. Key ingredients include Caprylic/Capric Triglyceride, Cetearyl Alcohol, Shea Butter.

Complete your skin profile to see how well this product matches your skin

Set up your skin profile
Perricone MD

Perricone MD

Perricone MD Hypoallergenic Clean Correction Nourishing Moisturiser 59ml

Moisturizer

$81.2859ml · $1.38/ml

★★★★★4.7(956)

Ideal for

  • StrongDryness
  • RelevantFine lines & wrinkles

Not recommended for

Seborrheic Dermatitis

Perricone MD Hypoallergenic Clean Correction Nourishing Moisturiser 59ml is a antioxidant serum by Perricone MD. Key ingredients include Betaine, Coco-Caprylate, Glycerin.

Complete your skin profile to see how well this product matches your skin

Set up your skin profile
Perricone MD

Perricone MD

Perricone MD High Potency Intensive Niacinamide-rich Smoothing Serum 59ml

Serum

$42.1659ml · $0.71/ml

★★★★★4.7(990)

Ideal for

  • ExcellentDryness
  • StrongFine lines & wrinkles
  • StrongRedness & sensitivity
  • RelevantDark spots & hyperpigmentation

Not recommended for

Seborrheic Dermatitis

Perricone MD High Potency Intensive Niacinamide-rich Smoothing Serum 59ml is a brightening serum by Perricone MD. Key ingredients include Niacinamide, Dimethicone, Glyceryl Stearate.

Complete your skin profile to see how well this product matches your skin

Set up your skin profile
Medik8

Medik8

Medik8 Crystal Retinal 1 Serum 30ml

Serum

$57.1530ml · $1.91/ml

★★★★★4.7(3,719)

Ideal for

  • ExcellentDryness
  • StrongFine lines & wrinkles

Not recommended for

Seborrheic Dermatitis

Medik8 Crystal Retinal 1 Serum 30ml is a retinoid treatment by Medik8. Key ingredients include Water, Caprylic/Capric Triglyceride, Glycerin.

Complete your skin profile to see how well this product matches your skin

Set up your skin profile

Educational information, not medical advice. Study findings summarise the cited research and may not reflect every formulation.