botanical
Triterpene constituents (asiaticoside, madecassoside, asiatic acid) stimulate collagen synthesis in fibroblasts, inhibit keloid formation, and modulate NF-κB inflammation.
| Concern | Strength | Studies | What the research says |
|---|---|---|---|
| Acne & breakouts | Relevant | 1 | Clinical study (n=88, 4 weeks): SS 10 global score reduced by 66% at 2 weeks and 76% at 4 weeks; significantly reduced skin irritation tautness itching redness; TEWL decreased at weeks 1 and 2; SCH increased at all time… |
| Redness & sensitivity | Relevant | 3 | Systematic review of centella in dermatology: asiaticoside and madecassoside stimulate type I collagen synthesis, reduce inflammation via NF-κB inhibition, and promote wound healing; clinical evidence supports use for… |
| Fine lines & wrinkles | Relevant | 4 | Systematic review of centella in dermatology: asiaticoside and madecassoside stimulate type I collagen synthesis, reduce inflammation via NF-κB inhibition, and promote wound healing; clinical evidence supports use for… |
No known conflicts — Centella Asiatica isn’t flagged against any concern or skin condition.
Strength reflects the ingredient’s effect on each concern; study counts match research whose findings relate to that concern.
Centella Asiatica is a botanical backed by a moderate body of supporting evidence (evidence tier 2 of 4). We track 10 studies for it, 8 reporting a positive effect. It is typically effective at 1–5% in a formulation.
Advances in Dermatology and Allergology · 2013 · systematic review
Systematic review of centella in dermatology: asiaticoside and madecassoside stimulate type I collagen synthesis, reduce inflammation via NF-κB inhibition, and promote wound healing; clinical evidence supports use for hypertrophic scars, burns, and barrier-impaired skin
Journal of Cosmetic Dermatology · 2024 · rct · n=64
Randomized controlled trial (n=64, 6 weeks): IGA score facial dryness facial flushing lesion severity significant improvement at weeks 3 and 6 p<0.05.
Journal of the American Academy of Dermatology · 2020 · rct
Randomized controlled trial: Erythema subsided earlier on ECa 233 treated side day 7 vs day 28 placebo; significant improvements in erythema p=0.009 day 2 p=0.0061 day 4 p=0.012 day 7; significant crusting improvement p=0.02 day 2; significant general wound appearance improvement p significant days 2 4 7.
Journal of Cosmetic Dermatology · 2025 · observational · n=88
Clinical study (n=88, 4 weeks): SS 10 global score reduced by 66% at 2 weeks and 76% at 4 weeks; significantly reduced skin irritation tautness itching redness; TEWL decreased at weeks 1 and 2; SCH increased at all time points; sebum increased at week 4; EI a value facial red area rapidly decreased.
Experimental Dermatology · 2008 · rct · n=20
Randomized double-blind trial (n=20 women, 6 months) of topical 5% vitamin C plus 0.1% madecassoside (a Centella asiatica triterpene) on photoaged skin: significant improvement in deep and superficial wrinkles, firmness, suppleness, roughness and hydration, with re-appearance of a normally structured elastic-fibre network in the papillary dermis.
Journal of Tissue Engineering and Regenerative Medicine · 2015 · animal · n=60
Rat wound model: electrospun gelatin membranes containing Centella asiatica extract gave the highest wound recovery rate versus gauze, plain gelatin and a commercial dressing, promoting fibroblast proliferation and collagen synthesis with antibacterial activity; supports Centella's pro-healing effect (animal data, not a human RCT).
+ 4 more studies in our evidence base.
In 1,417 products — most often serums (498), moisturizers (362), sunscreens (124), from $2.51 to $1020.00. Set up a profile to rank these for your skin. Click any product to learn more.
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Set up your skin profileEducational information, not medical advice. Study findings summarise the cited research and may not reflect every formulation.