Skin Research and Technology · 2024 · rct
Randomized controlled trial: Significant improvements in skin hydration Corneometer elasticity Cutometer collagen density ultrasound and visible appearance VISIA over 12 weeks.
peptide
Matrixyl 3000
Evidenceemerging · Tier 3Irritation riskVery lowIn products516
Signal peptide complex (Pal-GHK + Pal-GQPR) that upregulates collagen, elastin, and glycosaminoglycan synthesis via matrikine signalling. Evidence base is largely manufacturer-sponsored.
Concerns it helps
| Concern | Strength | Studies | What the research says |
|---|---|---|---|
| Loss of firmness | Relevant | — | Sederma-sponsored 2-month clinical study demonstrated nearly 20% skin tonicity increase. Multiple studies demonstrate cutometer-measured elasticity improvements. Schmidt 2020 EADV age spots/wrinkles study showed… |
| Fine lines & wrinkles | Relevant | 6 | Matrixyl 3000 has substantial wrinkle reduction evidence base across multiple clinical studies, all demonstrating statistically significant improvements. Sederma-sponsored 24-subject cream study with Matrixyl 3000 twice… |
No known conflicts — Matrixyl 3000 isn’t flagged against any concern or skin condition.
Strength reflects the ingredient’s effect on each concern; study counts match research whose findings relate to that concern.
The research
Matrixyl 3000 is a peptide backed by early but promising evidence (evidence tier 3 of 4). We track 7 studies for it, 6 reporting a positive effect.
Read the research — 7 studiesHide the research
Journal of Cosmetic Dermatology · 2023 · rct · n=32
Randomized controlled trial (n=32, 4 weeks): Wrinkle parameter improvements plus hydration skin elasticity and firmness improvements.
Matrixyl 3000 clinical study program
Q40Matrixyl 3000 clinical study program · 2005 · observational
Clinical study: Clinical evidence base demonstrating Matrixyl 3000 anti aging efficacy across multiple indications and formulations; industry funded concentration warrants user Q4 evidence penalty framework application.
Palmitoyl Tetrapeptide-7 Anti-Aging Research
Q20November 2025 · 2025 · in vitro
In-vitro/mechanistic study: Consolidated evidence review documenting 68% deep wrinkle surface area reduction 6 month progressive improvement plus retinoid comparison framework with industry funded evidence transparency.
Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7: The Peptides That Make Up Matrixyl 3000
Q0March 2026 · 2026 · review
Review: Recent 2026 consolidated review consolidating Matrixyl 3000 mechanism and clinical evidence including 12 week 53 woman study 2.4% collagen fiber density increase and eye contour cream evidence.
Matrixyl 3000: Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 guide
Q0March 2026 · 2026 · review
Review: Recent 2026 consolidated review documenting profilometric 15 to 30% periorbital wrinkle depth decrease and pH 3.5 to 7 stability range plus industry funded evidence concentration transparency.
+ 1 more studies in our evidence base.
Products with Matrixyl 3000
In 516 products — most often serums (211), moisturizers (139), eye creams (83), from $5.00 to $745.83. Set up a profile to rank these for your skin. Click any product to learn more.
10 of 24
SKIN1004
SKIN1004 Madagascar Centella Poremizing Fresh Ampoule 100ml
Serum
$25.00100ml · $0.25/ml
★★★★★4.9(602)
Ideal for
- ExcellentDryness
- StrongRedness & sensitivity
- StrongFine lines & wrinkles
SKIN1004
SKIN1004 Madagascar Centella Poremizing Fresh Ampoule 100ml
Serum
$25.00100ml · $0.25/ml
★★★★★4.9(602)
Ideal for
- ExcellentDryness
- StrongRedness & sensitivity
- StrongFine lines & wrinkles
SKIN1004 Madagascar Centella Poremizing Fresh Ampoule 100ml is a peptide serum by SKIN1004. Key ingredients include Centella Asiatica, Water, Butylene Glycol.
Product Ingredients (18)
Irritation risk: unlikely possible likely
Centella Asiatica50.47%WaterButylene GlycolPropanediol1,2-HexanediolAloe Barbadensis Leaf ExtractGlycerinCarbomerTromethaminePanthenolEthylhexylglycerinDisodium EDTADipotassium GlycyrrhizateHyaluronic AcidHydroxyethylcelluloseChamomilla Recutita Flower ExtractMatrixyl (Palmitoyl Pentapeptide-4)Matrixyl 3000
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Nip + Fab
NIP+FAB Peptide Fix Melting Jelly Cleanser 120ml
Cleanser
$21.53120ml · $0.18/ml
★★★★★4.8(720)
Ideal for
- RelevantDark spots & hyperpigmentation
Not recommended for
Acne & breakoutsSeborrheic Dermatitis
Nip + Fab
NIP+FAB Peptide Fix Melting Jelly Cleanser 120ml
Cleanser
$21.53120ml · $0.18/ml
★★★★★4.8(720)
Ideal for
- RelevantDark spots & hyperpigmentation
Not recommended for
Acne & breakoutsSeborrheic Dermatitis
NIP+FAB Peptide Fix Melting Jelly Cleanser 120ml is a water cleanser by Nip + Fab. Key ingredients include Sweet Almond Oil, Caprylic/Capric Triglyceride, Silica.
Product Ingredients (10)
Irritation risk: unlikely possible likely
Complete your skin profile to see how well this product matches your skin
Set up your skin profile
Nip + Fab
NIP+FAB Retinol Fix Concentrate Extreme 10% 30ml
Serum
$38.0430ml · $1.27/ml
★★★★★4.8(704)
Ideal for
- StrongDryness
- StrongFine lines & wrinkles
- RelevantDark spots & hyperpigmentation
- RelevantLoss of firmness
Not recommended for
MelasmaAtopic Dermatitis / EczemaPsoriasisRosaceaPerioral Dermatitis
Nip + Fab
NIP+FAB Retinol Fix Concentrate Extreme 10% 30ml
Serum
$38.0430ml · $1.27/ml
★★★★★4.8(704)
Ideal for
- StrongDryness
- StrongFine lines & wrinkles
- RelevantDark spots & hyperpigmentation
- RelevantLoss of firmness
Not recommended for
MelasmaAtopic Dermatitis / EczemaPsoriasisRosaceaPerioral Dermatitis
NIP+FAB Retinol Fix Concentrate Extreme 10% 30ml is a retinoid treatment by Nip + Fab. Key ingredients include Polysorbate 20, Glycerin, Caprylic/Capric Triglyceride.
Product Ingredients (21)
Irritation risk: unlikely possible likely
Complete your skin profile to see how well this product matches your skin
Set up your skin profile
Nip + Fab
NIP+FAB Retinol Fix Overnight Treatment Cream 3% 50ml
Moisturizer
$38.0450ml · $0.76/ml
★★★★★4.8(724)
Ideal for
- ExcellentDryness
- StrongFine lines & wrinkles
- RelevantDark spots & hyperpigmentation
- RelevantLoss of firmness
Not recommended for
Seborrheic DermatitisMelasmaAtopic Dermatitis / EczemaPsoriasisRosaceaPerioral Dermatitis
Nip + Fab
NIP+FAB Retinol Fix Overnight Treatment Cream 3% 50ml
Moisturizer
$38.0450ml · $0.76/ml
★★★★★4.8(724)
Ideal for
- ExcellentDryness
- StrongFine lines & wrinkles
- RelevantDark spots & hyperpigmentation
- RelevantLoss of firmness
Not recommended for
Seborrheic DermatitisMelasmaAtopic Dermatitis / EczemaPsoriasisRosaceaPerioral Dermatitis
NIP+FAB Retinol Fix Overnight Treatment Cream 3% 50ml is a retinoid treatment by Nip + Fab. Key ingredients include Glycerin, Glyceryl Stearate SE, Caprylic/Capric Triglyceride.
Product Ingredients (27)
Irritation risk: unlikely possible likely
GlycerinGlyceryl Stearate SECaprylic/Capric TriglycerideShea ButterDimethiconeCetearyl AlcoholRetinolBenzyl AlcoholButylene GlycolFragrancePhenoxyethanolSodium Stearoyl GlutamateVitamin EDisodium EDTABakuchiolHyaluronic AcidPolyglyceryl-10 StearateCeramidesCarbomerGlyceryl StearatePolysorbate 20Matrixyl 3000Benzyl SalicylateCoumarinHexyl CinnamalLimoneneLinalool
Complete your skin profile to see how well this product matches your skin
Set up your skin profileDIME
TBT Serum with Mandelic Acid + Peptides
Serum
$38.0029.6ml · $1.28/ml
★★★★★4.8(7,487)
Ideal for
- ExcellentDryness
- StrongDark spots & hyperpigmentation
- StrongFine lines & wrinkles
- StrongAcne & breakouts
DIME
TBT Serum with Mandelic Acid + Peptides
Serum
$38.0029.6ml · $1.28/ml
★★★★★4.8(7,487)
Ideal for
- ExcellentDryness
- StrongDark spots & hyperpigmentation
- StrongFine lines & wrinkles
- StrongAcne & breakouts
TBT Serum with Mandelic Acid + Peptides is a retinoid treatment by DIME. Key ingredients include Water, Mandelic Acid, Propanediol.
Product Ingredients (11)
Irritation risk: unlikely possible likely
Complete your skin profile to see how well this product matches your skin
Set up your skin profileBubble
Eye Cream
$14.9914.8ml · $1.01/ml
★★★★★4.8(920)
Ideal for
- ExcellentDryness
- StrongDark spots & hyperpigmentation
- StrongFine lines & wrinkles
- RelevantUneven texture
Not recommended for
Seborrheic DermatitisAtopic Dermatitis / EczemaRosaceaPsoriasis
Bubble
Eye Cream
$14.9914.8ml · $1.01/ml
★★★★★4.8(920)
Ideal for
- ExcellentDryness
- StrongDark spots & hyperpigmentation
- StrongFine lines & wrinkles
- RelevantUneven texture
Not recommended for
Seborrheic DermatitisAtopic Dermatitis / EczemaRosaceaPsoriasis
Star Dew Hydrating Eye Cream is a eye cream by Bubble. Key ingredients include Water, Glycerin, Squalane.
Product Ingredients (17)
Irritation risk: unlikely possible likely
Complete your skin profile to see how well this product matches your skin
Set up your skin profileThe INKEY List
Hyaluronic Acid Hydrating Face Serum
Serum
$13.0029.6ml · $0.44/ml
★★★★★4.8(2,448)
Ideal for
- StrongDryness
- StrongFine lines & wrinkles
The INKEY List
Hyaluronic Acid Hydrating Face Serum
Serum
$13.0029.6ml · $0.44/ml
★★★★★4.8(2,448)
Ideal for
- StrongDryness
- StrongFine lines & wrinkles
Hyaluronic Acid Hydrating Face Serum is a peptide serum by The INKEY List. Key ingredients include Water, Propanediol, Hyaluronic Acid.
Product Ingredients (10)
Irritation risk: unlikely possible likely
Complete your skin profile to see how well this product matches your skin
Set up your skin profile
Elizabeth Arden
Elizabeth Arden Retinol + HPR Ceramide Capsules Rapid Skin Renewing Serum 90 Capsules
Serum
$125.73
★★★★★4.8(978)
Ideal for
- ExcellentDryness
- StrongFine lines & wrinkles
- RelevantLoss of firmness
- RelevantDark spots & hyperpigmentation
Not recommended for
Seborrheic DermatitisAtopic Dermatitis / EczemaPsoriasis
Elizabeth Arden
Elizabeth Arden Retinol + HPR Ceramide Capsules Rapid Skin Renewing Serum 90 Capsules
Serum
$125.73
★★★★★4.8(978)
Ideal for
- ExcellentDryness
- StrongFine lines & wrinkles
- RelevantLoss of firmness
- RelevantDark spots & hyperpigmentation
Not recommended for
Seborrheic DermatitisAtopic Dermatitis / EczemaPsoriasis
Elizabeth Arden Retinol + HPR Ceramide Capsules Rapid Skin Renewing Serum 90 Capsules is a retinoid treatment by Elizabeth Arden. Key ingredients include Cyclopentasiloxane, Dimethicone, C12-15 Alkyl Benzoate.
Product Ingredients (14)
Irritation risk: unlikely possible likely
Complete your skin profile to see how well this product matches your skin
Set up your skin profile
Perricone MD
Perricone MD Neuropeptide Pro-Strength Firming Moisturiser
Moisturizer – for Dryness, Redness & sensitivity
$175.26
★★★★★4.8(984)
Ideal for
- ExcellentDryness
- StrongFine lines & wrinkles
- StrongRedness & sensitivity
Not recommended for
Seborrheic DermatitisAtopic Dermatitis / EczemaRosaceaPerioral DermatitisPsoriasisMelasma
Perricone MD
Perricone MD Neuropeptide Pro-Strength Firming Moisturiser
Moisturizer – for Dryness, Redness & sensitivity
$175.26
★★★★★4.8(984)
Ideal for
- ExcellentDryness
- StrongFine lines & wrinkles
- StrongRedness & sensitivity
Not recommended for
Seborrheic DermatitisAtopic Dermatitis / EczemaRosaceaPerioral DermatitisPsoriasisMelasma
Perricone MD Neuropeptide Pro-Strength Firming Moisturiser is a antioxidant serum by Perricone MD. Key ingredients include Glycerin, Caprylic/Capric Triglyceride, Cetearyl Alcohol.
Product Ingredients (36)
Irritation risk: unlikely possible likely
GlycerinCaprylic/Capric TriglycerideCetearyl AlcoholDimethiconeShea ButterCetearyl OlivateSorbitan OlivateSodium PCAButylene GlycolVitamin E1,2-HexanediolCaprylyl GlycolAllantoinSodium Lauroyl LactylateDecyl GlucosideFragranceCarbomerCitric AcidPhenoxyethanolCeramidesPolysorbate 20Glyceryl StearateHyaluronic AcidCeteareth-25CholesterolXanthan GumEthylhexylglycerinMatrixyl (Palmitoyl Pentapeptide-4)Stearyl AlcoholMatrixyl 3000LecithinPotassium SorbateCitronellolHydroxycitronellalLimoneneLinalool
Complete your skin profile to see how well this product matches your skin
Set up your skin profile
Elizabeth Arden
Elizabeth Arden Retinol + HPR Ceramide Capsules Rapid Skin Renewing Serum 60 Capsules
Serum
$107.95
★★★★★4.8(977)
Ideal for
- ExcellentDryness
- StrongFine lines & wrinkles
- RelevantLoss of firmness
- RelevantDark spots & hyperpigmentation
Not recommended for
Seborrheic DermatitisAtopic Dermatitis / EczemaPsoriasis
Elizabeth Arden
Elizabeth Arden Retinol + HPR Ceramide Capsules Rapid Skin Renewing Serum 60 Capsules
Serum
$107.95
★★★★★4.8(977)
Ideal for
- ExcellentDryness
- StrongFine lines & wrinkles
- RelevantLoss of firmness
- RelevantDark spots & hyperpigmentation
Not recommended for
Seborrheic DermatitisAtopic Dermatitis / EczemaPsoriasis
Elizabeth Arden Retinol + HPR Ceramide Capsules Rapid Skin Renewing Serum 60 Capsules is a retinoid treatment by Elizabeth Arden. Key ingredients include Cyclopentasiloxane, Dimethicone, C12-15 Alkyl Benzoate.
Product Ingredients (14)
Irritation risk: unlikely possible likely
Complete your skin profile to see how well this product matches your skin
Set up your skin profileEducational information, not medical advice. Study findings summarise the cited research and may not reflect every formulation.