Pharmaceutics · 2024 · in vitro
Ionic liquids pairing epsilon-caprolactam with fatty acids (C8 to C18:1, including myristic acid/C14 as the original prototype) were tested as Azone-like skin-penetration enhancers; the C12 lauric-acid variant gave the strongest enhancement, exceeding Azone, indicating myristic-acid-based enhancers are effective but chain-length dependent.



