Dermatology and Therapy · 2015 · systematic review · n=120
Systematic review of keratolytics and emollients in psoriasis therapy: salicylic acid is a key keratolytic that removes psoriatic scale and improves penetration of co-applied topical agents; supports salicylic acid as an evidence-based adjunctive (descaling) treatment rather than a standalone therapy.
Clinical, Cosmetic and Investigational Dermatology · 2015 · systematic review
Comprehensive review: salicylic acid (2%) is the only lipophilic BHA, enabling comedolytic and anti-inflammatory activity within the pilosebaceous unit; effective for acne vulgaris, melasma, photodamage, and keratosis pilaris; 20-30% SA peels show efficacy comparable to glycolic acid peels with lower erythema risk in Fitzpatrick IV-VI
Journal of the European Academy of Dermatology and Venereology · 2011 · rct · n=50
Single-blind RCT (n=46, 12 weeks) in mild-to-moderate acne comparing salicylic acid 3% plus clindamycin with tretinoin 0.05% plus clindamycin: both significantly reduced inflammatory and non-inflammatory lesion counts; tretinoin acted faster (significant by week 2) but groups were comparable at 12 weeks, and both were well tolerated.
Treatment of acne vulgaris with salicylic acid pads
Q75Clinical Therapeutics · 1992 · systematic review
This review of four placebo-controlled clinical studies and a comedolytic assay found that 0.5% and 2% salicylic acid pads reduced the number and severity of acne lesions in mild-to-moderate acne vulgaris. Comparative data showed salicylic acid superior to benzoyl peroxide, with adverse effects limited to mild local irritation.
Jessner's solution vs. 30% salicylic acid peels: a comparative study of the efficacy and safety in mild‐to‐moderate acne vulgaris
Q65Journal of Cosmetic Dermatology · 2016 · rct
Randomized controlled trial: Comparable efficacy of salicylic to Jessner.
Dermatologic Surgery · 2013 · rct
Randomized controlled trial: Salicylic vs Jessner equivalent efficacy better tolerability for salicylic.
+ 7 more studies in our evidence base.