Oral hydrolysed collagen peptides (2.5–10 g/day) are absorbed as di- and tripeptides (Pro-Hyp, Hyp-Gly) that may stimulate dermal fibroblast proliferation and collagen/HA synthesis; however, funding-stratified meta-analyses show null effects in independently funded trials.
The research
Oral Collagen Peptides is a oral supplement backed by early but promising evidence (evidence tier 3 of 4). We track 5 studies for it, 5 reporting a positive effect.
International Journal of Dermatology · 2021 · meta analysis · n=1474
Systematic review and meta-analysis of clinical trials: 90-day oral hydrolyzed collagen supplementation was effective in reducing skin aging, decreasing wrinkles and improving skin elasticity and hydration versus placebo.
Meta-analysis of 26 RCTs (n=1,721): oral hydrolyzed collagen significantly improved skin hydration (SMD 0.63, p<0.00001) and elasticity (SMD 0.72, p<0.00001); fish-derived collagen and >8-week supplementation gave the best results; authors call for larger confirmatory trials.
Dermatology Research and Practice · 2024 · rct · n=60
Randomized, double-blind, placebo-controlled trial of an oral hydrolysed collagen plus vitamin C supplement over 12 weeks: confocal microscopy and high-resolution ultrasound showed reduced dermal collagen fragmentation, with improved skin hydration, elasticity, and wrinkles versus placebo; manufacturer-funded.
Double-blind RCT (n=72): oral collagen peptides 2.5 g/day significantly improved skin hydration, elasticity, roughness, and density versus placebo at 12 weeks; improvements continued at 4-week follow-up; entirely industry-funded by GELITA AG
Skin Pharmacology and Physiology · 2014 · rct · n=69
Porcine collagen peptides 2.5 g and 5 g/day both significantly improved skin elasticity versus placebo at 8 weeks (p<0.05); 5 g group showed greater effect (+7.2% vs +0.9%); skin moisture improved only in the >50 years subgroup; GELITA AG-funded with employees as co-authors
Products with Oral Collagen Peptides
In 135 products — most often moisturizers (52), serums (43), masks (20), from $4.75 to $114.30. Set up a profile to rank these for your skin. Click any product to learn more.
111SKIN Rose Gold Brightening Facial Treatment Mask (Various Options) is a peptide serum by 111SKIN. Key ingredients include Glycerin, Dipropylene Glycol, Algae Extract.
BARBER PRO Under Eye Mask with Activated Charcoal and Volcanic Ash (3 Applications) is a eye cream by BARBER PRO. Key ingredients include Oral Collagen Peptides, Camellia Sinensis Leaf Extract.
Dose & Co Beauty Collagen with Hyaluronic Acid and Vitamin C Powder 255g is a skincare product by Dose & Co. Key ingredients include Oral Collagen Peptides, Hyaluronic Acid, L-Ascorbic Acid.