Journal of Investigative Dermatology · 2024 · in vitro
In keratinocytes, trehalose prevented IL-4/IL-13-induced impairment of the skin barrier, an effect linked to suppression of IL-33 expression and increased Nrf2 pathway activation.
humectant
Trehalose
Evidenceemerging · Tier 3Irritation riskVery lowIn products850
Concerns it helps
| Concern | Strength | Studies | What the research says |
|---|---|---|---|
| Dryness | Relevant | 1 | In keratinocytes, trehalose prevented IL-4/IL-13-induced impairment of the skin barrier, an effect linked to suppression of IL-33 expression and increased Nrf2 pathway activation. |
No known conflicts — Trehalose isn’t flagged against any concern or skin condition.
Strength reflects the ingredient’s effect on each concern; study counts match research whose findings relate to that concern.
The research
Trehalose is a humectant backed by early but promising evidence (evidence tier 3 of 4). We track 2 studies for it, 2 reporting a positive effect.
Read the research — 2 studiesHide the research
Biomedical Reports · 2014 · in vitro
In immortalized human HaCaT keratinocytes, trehalose-loaded liposomes reduced UVB-induced molecular photodamage and performed better than other common cytoprotective compounds tested; liposomes were used to overcome trehalose's low skin permeability.
Products with Trehalose
In 850 products — most often moisturizers (288), serums (288), masks (93), from $3.00 to $1786.24. Set up a profile to rank these for your skin. Click any product to learn more.
10 of 24
RODAN + FIELDS
Redefine Minimizing+ Pore Refining Toner
Toner
$50.00124.2ml · $0.40/ml
★★★★★4.8(4,564)
Ideal for
- ExcellentDryness
- RelevantRedness & sensitivity
- RelevantDark spots & hyperpigmentation
- RelevantUneven tone & radiance
Not recommended for
MelasmaAtopic Dermatitis / EczemaRosaceaPerioral DermatitisPsoriasis
RODAN + FIELDS
Redefine Minimizing+ Pore Refining Toner
Toner
$50.00124.2ml · $0.40/ml
★★★★★4.8(4,564)
Ideal for
- ExcellentDryness
- RelevantRedness & sensitivity
- RelevantDark spots & hyperpigmentation
- RelevantUneven tone & radiance
Not recommended for
MelasmaAtopic Dermatitis / EczemaRosaceaPerioral DermatitisPsoriasis
Redefine Minimizing+ Pore Refining Toner is a brightening serum by RODAN + FIELDS. Key ingredients include Glycerin, Butylene Glycol, Niacinamide.
Product Ingredients (14)
Irritation risk: unlikely possible likely
Complete your skin profile to see how well this product matches your skin
Set up your skin profileOSEA
Dream Night Serum with Bio-Retinol
Serum
$88.0029.6ml · $2.97/ml
★★★★★4.8(532)
Ideal for
- ExcellentDryness
- StrongFine lines & wrinkles
- RelevantUneven texture
- RelevantDark spots & hyperpigmentation
Not recommended for
RosaceaAtopic Dermatitis / EczemaPsoriasis
OSEA
Dream Night Serum with Bio-Retinol
Serum
$88.0029.6ml · $2.97/ml
★★★★★4.8(532)
Ideal for
- ExcellentDryness
- StrongFine lines & wrinkles
- RelevantUneven texture
- RelevantDark spots & hyperpigmentation
Not recommended for
RosaceaAtopic Dermatitis / EczemaPsoriasis
Dream Night Serum with Bio-Retinol is a exfoliant by OSEA. Key ingredients include Glycerin, Propanediol, Hyaluronic Acid.
Product Ingredients (16)
Irritation risk: unlikely possible likely
Complete your skin profile to see how well this product matches your skin
Set up your skin profileMEDIHEAL
Serum
$8.80
★★★★★4.8(4,710)
Ideal for
- ExcellentDryness
- ExcellentRedness & sensitivity
- StrongFine lines & wrinkles
- RelevantDark spots & hyperpigmentation
Not recommended for
Seborrheic Dermatitis
MEDIHEAL
Serum
$8.80
★★★★★4.8(4,710)
Ideal for
- ExcellentDryness
- ExcellentRedness & sensitivity
- StrongFine lines & wrinkles
- RelevantDark spots & hyperpigmentation
Not recommended for
Seborrheic Dermatitis
Madecassoside Essential Mask is a calming serum by MEDIHEAL. Key ingredients include Water, Propanediol, Dipropylene Glycol.
Product Ingredients (19)
Irritation risk: unlikely possible likely
Complete your skin profile to see how well this product matches your skin
Set up your skin profileRoC
Retinol Correxion Deep Wrinkle Rich Cream Moisturizer
Moisturizer
$37.9950.3ml · $0.76/ml
★★★★★4.8(1,308)
Ideal for
- ExcellentDryness
- StrongFine lines & wrinkles
- StrongRedness & sensitivity
- RelevantUneven texture
Not recommended for
Seborrheic DermatitisAtopic Dermatitis / EczemaPsoriasis
RoC
Retinol Correxion Deep Wrinkle Rich Cream Moisturizer
Moisturizer
$37.9950.3ml · $0.76/ml
★★★★★4.8(1,308)
Ideal for
- ExcellentDryness
- StrongFine lines & wrinkles
- StrongRedness & sensitivity
- RelevantUneven texture
Not recommended for
Seborrheic DermatitisAtopic Dermatitis / EczemaPsoriasis
Retinol Correxion Deep Wrinkle Rich Cream Moisturizer is a retinoid treatment by RoC. Key ingredients include Water, Glycerin, Glyceryl Stearate SE.
Product Ingredients (25)
Irritation risk: unlikely possible likely
WaterGlycerinGlyceryl Stearate SECetearyl AlcoholCetyl AlcoholIsopropyl PalmitateDimethiconeRetinolHyaluronic AcidCeramidesSodium PCAVitamin EHydrogenated LecithinUreaTrehaloseAllantoinCholesterolStearic AcidPolysorbate 20Xanthan Gum1,2-HexanediolCitric AcidPropanediolSodium HydroxideCaprylyl Glycol
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Set up your skin profile
Estée Lauder
Moisturizer
$57.1550ml · $1.14/ml
★★★★★4.8(581)
Ideal for
- ExcellentDryness
- RelevantFine lines & wrinkles
- RelevantUneven texture
Not recommended for
Acne & breakoutsSeborrheic DermatitisPerioral DermatitisAtopic Dermatitis / EczemaRosaceaPsoriasisMelasma
Estée Lauder
Moisturizer
$57.1550ml · $1.14/ml
★★★★★4.8(581)
Ideal for
- ExcellentDryness
- RelevantFine lines & wrinkles
- RelevantUneven texture
Not recommended for
Acne & breakoutsSeborrheic DermatitisPerioral DermatitisAtopic Dermatitis / EczemaRosaceaPsoriasisMelasma
Estée Lauder DayWear Sheer Tint Release Advanced Multi-Protection Anti-Oxidant Moisturizer SPF15 50ml is a spf moisturiser by Estée Lauder. Key ingredients include Octinoxate, Octisalate, Dimethicone.
Product Ingredients (35)
Irritation risk: unlikely possible likely
OctinoxateOctisalateDimethiconeButylene GlycolCyclopentasiloxaneAvobenzonePentylene GlycolHydrogenated LecithinCamellia Sinensis Leaf ExtractRosmarinus Officinalis Leaf ExtractCholesterolHyaluronic AcidTrehaloseLecithinSqualaneLinoleic AcidGlycerinSodium PCAUreaCaprylic/Capric TriglycerideIsopropyl MyristateTromethamineStearyl AlcoholCarbomerSodium HydroxideFragranceLinaloolBenzyl SalicylateDisodium EDTASodium BenzoatePotassium SorbateChlorphenesinPhenoxyethanolIron OxidesTitanium Dioxide
Complete your skin profile to see how well this product matches your skin
Set up your skin profile
ESPA
ESPA Tri-Active Lift and Firm Moisturiser 55ml
Moisturizer – for Dryness, Fine lines & wrinkles
$73.6655ml · $1.34/ml
★★★★★4.8(1,002)
Ideal for
- StrongDryness
- RelevantFine lines & wrinkles
Not recommended for
Seborrheic DermatitisRosacea
ESPA
ESPA Tri-Active Lift and Firm Moisturiser 55ml
Moisturizer – for Dryness, Fine lines & wrinkles
$73.6655ml · $1.34/ml
★★★★★4.8(1,002)
Ideal for
- StrongDryness
- RelevantFine lines & wrinkles
Not recommended for
Seborrheic DermatitisRosacea
ESPA Tri-Active Lift and Firm Moisturiser 55ml is a antioxidant serum by ESPA. Key ingredients include Water, Glycerin, Cetyl Alcohol.
Product Ingredients (25)
Irritation risk: unlikely possible likely
Complete your skin profile to see how well this product matches your skin
Set up your skin profile
Kérastase
Kérastase Resistance Therepiste Serum 30ml
Serum
$66.0430ml · $2.20/ml
★★★★★4.8(590)
Ideal for
- StrongDryness
Not recommended for
Seborrheic DermatitisRosacea
Kérastase
Kérastase Resistance Therepiste Serum 30ml
Serum
$66.0430ml · $2.20/ml
★★★★★4.8(590)
Ideal for
- StrongDryness
Not recommended for
Seborrheic DermatitisRosacea
Kérastase Resistance Therepiste Serum 30ml is a hydrating serum by Kérastase. Key ingredients include Cyclopentasiloxane, Dimethiconol, Dimethicone.
Product Ingredients (16)
Irritation risk: unlikely possible likely
Complete your skin profile to see how well this product matches your skin
Set up your skin profile
Augustinus Bader
Augustinus Bader The Vitamin C Serum 30ml
Serum – for Dryness, Dark spots & hyperpigmentation
$380.0030ml · $12.67/ml
★★★★★4.8(646)
Ideal for
- ExcellentDryness
- StrongFine lines & wrinkles
- StrongRedness & sensitivity
- RelevantDark spots & hyperpigmentation
Augustinus Bader
Augustinus Bader The Vitamin C Serum 30ml
Serum – for Dryness, Dark spots & hyperpigmentation
$380.0030ml · $12.67/ml
★★★★★4.8(646)
Ideal for
- ExcellentDryness
- StrongFine lines & wrinkles
- StrongRedness & sensitivity
- RelevantDark spots & hyperpigmentation
Augustinus Bader The Vitamin C Serum 30ml is a peptide serum by Augustinus Bader. Key ingredients include Propanediol, Pentylene Glycol, Niacinamide.
Product Ingredients (19)
Irritation risk: unlikely possible likely
Complete your skin profile to see how well this product matches your skin
Set up your skin profile
Clinique
Clinique Daily Calm™ Soothing Repair Cream 50ml
Moisturizer
$57.1550ml · $1.14/ml
★★★★★4.8(2,875)
Ideal for
- ExcellentDryness
- RelevantFine lines & wrinkles
- RelevantRedness & sensitivity
Not recommended for
Seborrheic Dermatitis
Clinique
Clinique Daily Calm™ Soothing Repair Cream 50ml
Moisturizer
$57.1550ml · $1.14/ml
★★★★★4.8(2,875)
Ideal for
- ExcellentDryness
- RelevantFine lines & wrinkles
- RelevantRedness & sensitivity
Not recommended for
Seborrheic Dermatitis
Clinique Daily Calm™ Soothing Repair Cream 50ml is a antioxidant serum by Clinique. Key ingredients include Shea Butter, Glycerin, Butylene Glycol.
Product Ingredients (20)
Irritation risk: unlikely possible likely
Complete your skin profile to see how well this product matches your skin
Set up your skin profile
Elizabeth Arden
Elizabeth Arden Prevage Anti-Aging Daily Serum 2.0 1.7 oz
Serum
$250.1950.3ml · $4.98/ml
★★★★★4.7(4,631)
Ideal for
- ExcellentDryness
- StrongFine lines & wrinkles
- RelevantUneven texture
Not recommended for
Atopic Dermatitis / EczemaRosaceaPerioral DermatitisPsoriasisMelasma
Elizabeth Arden
Elizabeth Arden Prevage Anti-Aging Daily Serum 2.0 1.7 oz
Serum
$250.1950.3ml · $4.98/ml
★★★★★4.7(4,631)
Ideal for
- ExcellentDryness
- StrongFine lines & wrinkles
- RelevantUneven texture
Not recommended for
Atopic Dermatitis / EczemaRosaceaPerioral DermatitisPsoriasisMelasma
Elizabeth Arden Prevage Anti-Aging Daily Serum 2.0 1.7 oz is a peptide serum by Elizabeth Arden. Key ingredients include Dimethicone, Cyclopentasiloxane, Butylene Glycol.
Product Ingredients (33)
Irritation risk: unlikely possible likely
DimethiconeCyclopentasiloxaneButylene GlycolC12-15 Alkyl BenzoateGlycerinDimethicone CrosspolymerPropanediolHydrogenated LecithinAmmonium Acryloyldimethyltaurate/VP CopolymerCaprylyl GlycolCarbomerCitric AcidDimethicone/Vinyl Dimethicone CrosspolymerHydroxyethylcelluloseLauryl GlucosideMicaPEG-100 StearatePEG-40 Hydrogenated Castor OilMatrixyl 3000FragrancePolysorbate 20SilicaHyaluronic AcidSodium Laureth SulfateSodium PCAVitamin ETrehaloseUreaXanthan GumHydroxycitronellalChlorphenesinPhenoxyethanolTitanium Dioxide
Complete your skin profile to see how well this product matches your skin
Set up your skin profileEducational information, not medical advice. Study findings summarise the cited research and may not reflect every formulation.